I shot one of these a few months ago at the range. My advice is to stick with using 38 Special ammo with it. Since it is a pretty lightweight side arm.
They also make for a pretty good investment. As it seems that all of the Post WWII Colts are rapidly going up in value. I myself just can not believe how much the prices at the Local Gun Shops lately
(As both the Python & later model Colt Troopers have a little more heft to them!)